Sugars
(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol
Quick view. A fluorinated C-aryl anhydro-D-ribitol derivative identified by CAS 875302-27-5. CAS 875302-27-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol is classified as sugars (Formula C12H14F2O4; molecular weight 260.23).
(1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2,4-Difluoro-5-methylphenyl anhydro-D-ribitol
Useful catalog search terms
- CAS 875302-27-5
Physicochemical data
| Carbohydrate scaffold | 1,4-anhydro-D-ribitol |
|---|---|
| Aryl substituent | 2,4-difluoro-5-methylphenyl |
| Linkage type | C-aryl |
| Free hydroxyl groups | 3 |
| InChIKey | RHKINGVHFDMCHO-KKOKHZNYSA-N |
| InChI | InChI=1S/C12H14F2O4/c1-5-2-6(8(14)3-7(5)13)12-11(17)10(16)9(4-15)18-12/h2-3,9-12,15-17H,4H2,1H3/t9-,10-,11-,12+/m1/s1 |
| SMILES | O[C@H]1[C@@H](O)[C@H](C2=C(F)C=C(F)C(C)=C2)O[C@@H]1CO |
| Canonical SMILES | O[C@H]1[C@@H](O)[C@H](C2=C(F)C=C(F)C(C)=C2)O[C@@H]1CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol or its named chemical feature. Broader product-family guidance is maintained on the category page.
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