Halogenated Nucleosides
2',3'-Dideoxy-3'-fluoro-5-methylcytidine
Quick view. 2',3'-Dideoxy-3'-fluoro-5-methylcytidine is a fluorinated cytidine nucleoside with CAS 115249-95-1. CAS 115249-95-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxy-3'-fluoro-5-methylcytidine is classified as fluorinated cytidine nucleoside (Formula C10H14FN3O3; molecular weight 243.23).
2',3'-Dideoxy-3'-fluoro-5-methylcytidine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',3'-Dideoxy-3'-fluoro-5-methylcytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 2',3'-dideoxy-3'-fluoro-5-methyl-
- Wikidata Q90559154
Useful catalog search terms
- CAS 115249-95-1
- YTMNCNXZZRCBFC-XLPZGREQSA-N
- PubChem CID 451565
Physicochemical data
| SMILES | CC1=CN(C(=O)N=C1N)[C@H]2C[C@@H]([C@H](O2)CO)F |
|---|---|
| Structural feature | 2',3'-dideoxy sugar bearing 3'-fluoro substitution |
| PubChem CID | 451565 |
| InChIKey | YTMNCNXZZRCBFC-XLPZGREQSA-N |
| InChI | InChI=1S/C10H14FN3O3/c1-5-3-14(10(16)13-9(5)12)8-2-6(11)7(4-15)17-8/h3,6-8,15H,2,4H2,1H3,(H2,12,13,16)/t6-,7+,8+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-3'-fluoro-5-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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