Halogenated Nucleosides
2',3'-Dideoxy-5-fluorocytidine
Quick view. 2',3'-Dideoxy-5-fluorocytidine is a 5-fluorinated dideoxycytidine derivative with CAS 107036-62-4. CAS 107036-62-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxy-5-fluorocytidine is classified as halogenated dideoxynucleoside (Formula C9H12FN3O3; molecular weight 229.21 (calculated from molecular formula)).
2',3'-Dideoxy-5-fluorocytidine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',3'-Dideoxy-5-fluorocytidine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Cytidine, 2',3'-dideoxy-5-fluoro-
Useful catalog search terms
- CAS 107036-62-4
- Halogenated Nucleosides
Physicochemical data
| InChI | InChI=1S/C9H12FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h3,5,7,14H,1-2,4H2,(H2,11,12,15)/t5-,7+/m0/s1 |
|---|---|
| InChIKey | QBEIABZPRBJOFU-CAHLUQPWSA-N |
| SMILES | C1C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)F |
| Structural features | 2',3'-Dideoxycytidine bearing fluorine at the 5-position |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3'-Dideoxy-5-fluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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