Modified Nucleosides
2'-Deoxy-2',2'-difluorocytidine
Quick view. Gemcitabine free base, a 2'-deoxycytidine derivative bearing geminal 2',2'-difluoro substitution. CAS 95058-81-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2',2'-difluorocytidine is classified as modified nucleosides (Formula C9H11F2N3O4; molecular weight 263.20 g/mol).
2'-Deoxy-2',2'-difluorocytidine — Geminally difluorinated cytidine compound for analytical comparison and modified-nucleoside route-development research.
For 2'-Deoxy-2',2'-difluorocytidine, form: Free base.
Names and search terms
Confirmed or normalized name variants
- Gemcitabine
- Gemcitabine free base
- 2',2'-Difluorodeoxycytidine
- dFdC
Useful catalog search terms
- 95058-81-4
- C9H11F2N3O4
Physicochemical data
| SMILES | C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F |
|---|---|
| InChIKey | SDUQYLNIPVEERB-QPPQHZFASA-N |
| Physical form | White crystalline powder |
| Nucleoside | 2'-Deoxycytidine |
| Sugar modification | 2',2'-Difluoro |
| Form | Free base |
| InChI | InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2',2'-difluorocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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