2'-F Nucleosides
2'-Deoxy-2'-fluoro-N1-methylinosine
Quick view. Modified inosine bearing fluorine at the 2'-position and a methyl substituent at N1. CAS 2376610-64-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-Deoxy-2'-fluoro-N1-methylinosine is classified as 2'-f nucleosides (Formula C11H13FN4O4; molecular weight 284.24 g/mol).
2'-Deoxy-2'-fluoro-N1-methylinosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Deoxy-2'-fluoro-N1-methylinosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2376610-64-7
Physicochemical data
| Nucleoside | Inosine |
|---|---|
| Substitution pattern | N1-methyl and 2'-deoxy-2'-fluoro |
| Stereochemical scope | Stereodefined ribofuranosyl configuration |
| InChIKey | PNJLEUCOHWPPCZ-HUKYDQBMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-N1-methylinosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.