2'-O-Me Nucleosides
2'-O-Methyl-N1-methyladenosine
Quick view. The modified adenosine m1Am, bearing N1-methyl and 2'-O-methyl substituents. CAS 91101-00-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
2'-O-Methyl-N1-methyladenosine is classified as 2'-o-me nucleosides (Formula C12H17N5O4; molecular weight 295.29 g/mol).
2'-O-Methyl-N1-methyladenosine — Modified adenosine building block and identity reference for RNA-modification research.
For 2'-O-Methyl-N1-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 1,2'-O-Dimethyladenosine
- N1,O2'-Dimethyladenosine
- m1Am
Useful catalog search terms
- 91101-00-7
- DJONVIMMDYQLKR-WOUKDFQISA-N
Physicochemical data
| Abbreviation | m1Am |
|---|---|
| InChIKey | DJONVIMMDYQLKR-WOUKDFQISA-N |
| SMILES | CN1C=NC2=C(C1=N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| Nucleoside | Adenosine |
| Sugar modification | 2'-O-Methyl |
| Base modification | N1-Methyl |
| InChI | InChI=1S/C12H17N5O4/c1-16-4-15-11-7(10(16)13)14-5-17(11)12-9(20-2)8(19)6(3-18)21-12/h4-6,8-9,12-13,18-19H,3H2,1-2H3/t6-,8-,9-,12-/m1/s1 |
| Canonical SMILES | CN1C=NC2=C(C1=N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| PubChem CID | 86751121 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N1-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2-Amino-2'-O-methyladenosine
2'-O-Me Nucleosides · CAS: 80791-87-3
OR-2OMN-00032'-O-Methyl-7-deazaadenosine
2'-O-Me Nucleosides · CAS: 68345-70-0
OR-2OMN-0004N6,2'-O-Dimethyladenosine
2'-O-Me Nucleosides · CAS: 57817-83-1
OR-2OMN-00052'-O-Methylinosine
2'-O-Me Nucleosides · CAS: 3881-21-8
OR-MN-01752'-O-Methylcytidine
2'-O-Me Nucleosides · CAS: 2140-72-9
OR-MN-01782'-O-Methylguanosine
2'-O-Me Nucleosides · CAS: 2140-71-8
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.