2'-FANA Nucleosides
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine
Quick view. A benzoyl-protected fluorinated arabinouridine derivative bearing a 2'-fluoro substituent and a 5-fluoro group on the uracil base. CAS 952651-49-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine is classified as 2'-fana nucleosides (Formula C23H18F2N2O7; molecular weight 472.40 g/mol).
3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine — Protected fluorinated arabinouridine building block for modified-nucleoside synthesis and downstream oligonucleotide chemistry.
For 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine, storage: Sealed in dry conditions at 2-8 C.
Names and search terms
Confirmed or normalized name variants
- ((2R,3R,4S,5R)-3-(benzoyloxy)-4-fluoro-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate
Useful catalog search terms
- 952651-49-9
- C23H18F2N2O7
Physicochemical data
| SMILES | C1=CC=C(C=C1)C(=O)OC[C@@H]2[C@H]([C@@H]([C@@H](O2)N3C=C(C(=O)NC3=O)F)F)OC(=O)C4=CC=CC=C4 |
|---|---|
| Sugar modification | 2'-Fluoro |
| Base modification | 5-Fluoro |
| Protecting groups | 3',5'-Di-O-benzoyl |
| PubChem CID | 118992198 |
| InChIKey | JVLYAOKVBRIBCM-AJYBTWMASA-N |
| InChI | InChI=1S/C23H18F2N2O7/c24-15-11-27(23(31)26-19(15)28)20-17(25)18(34-22(30)14-9-5-2-6-10-14)16(33-20)12-32-21(29)13-7-3-1-4-8-13/h1-11,16-18,20H,12H2,(H,26,28,31)/t16-,17+,18-,20-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-5-fluoro-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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