Halogenated Nucleosides
3'-Deoxy-3'-fluoroguanosine
Quick view. A guanosine nucleoside bearing fluorine at the 3' position of the ribofuranose unit, CAS 123402-21-1. CAS 123402-21-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-3'-fluoroguanosine is classified as halogenated nucleosides (Formula C10H12FN5O4; molecular weight 285.23).
Primary literature reports 3'-deoxy-3'-fluoroguanosine in a 3'-fluorinated purine nucleoside synthesis series.
For 3'-Deoxy-3'-fluoroguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-Fluoro-3'-deoxyguanosine
- Guanosine, 3'-deoxy-3'-fluoro-
- 3'-F-3'-dG
- 9-[3-Deoxy-3-C-fluoro-beta-D-ribofuranosyl]guanine
- 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Useful catalog search terms
- CAS 123402-21-1
Physicochemical data
| InChI | InChI=1S/C10H12FN5O4/c11-4-3(1-17)20-9(6(4)18)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1 |
|---|---|
| InChIKey | VDOWHLFGBWKXJC-DXTOWSMRSA-N |
| SMILES | N=c1nc(O)c2ncn([C@@H]3O[C@H](CO)[C@@H](F)[C@H]3O)c2[nH]1 |
| Nucleobase | Guanine |
| Sugar modification | 3'-fluoro-3'-deoxy |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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