Other Phosphoramidites
3'-O-MOE-5MeU-2'-phosphoramidite
Quick view. 5-methyluridine phosphoramidite bearing 5'-O-DMTr protection, a 3'-O-(2-methoxyethyl) substituent and a 2'-O-CED phosphoramidite group. CAS 256223-93-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-MOE-5MeU-2'-phosphoramidite is classified as other phosphoramidites (Formula C43H55N4O10P; molecular weight 818.90 g/mol).
3'-O-MOE-5MeU-2'-phosphoramidite is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-MOE-5MeU-2'-phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-3'-O-(2-methoxyethyl)-5-methyluridine-2'-CED-phosphoramidite
Useful catalog search terms
- 256223-93-5
Physicochemical data
| Systematic name | 3-[[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile |
|---|---|
| Chemical form | Neutral 5'-O-DMTr-protected, 3'-O-MOE-modified 5-methyluridine 2'-CED phosphoramidite |
| Structural scope | 5'-O-DMTr, 3'-O-(2-methoxyethyl) and 2'-O-CED phosphoramidite substitution |
| Stereochemical scope | Four defined ribose stereocenters; phosphorus configuration unspecified |
| InChIKey | KEZSAZVVRSGBSV-KZQAAKLLSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-MOE-5MeU-2'-phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.