Protected Nucleosides
3'-O-tert-Butyldiphenylsilylthymidine
Quick view. A thymidine derivative bearing a 3'-O-tert-butyldiphenylsilyl protecting group, identified by CAS 83467-48-5. CAS 83467-48-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
Request a quote Review request checklist
Product profile
3'-O-tert-Butyldiphenylsilylthymidine is classified as protected nucleosides (Formula C26H32N2O5Si; molecular weight 480.60).
3'-O-tert-Butyldiphenylsilylthymidine is associated with thymidine-containing building blocks or substrates for DNA synthesis and analytical comparison.
For 3'-O-tert-Butyldiphenylsilylthymidine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 3'-O-(t-Butyldiphenylsilyl)thymidine
- 3'-O-TBDPS-thymidine
Useful catalog search terms
- CAS 83467-48-5
- PubChem CID 11016319
Physicochemical data
| PubChem CID | 11016319 |
|---|---|
| InChIKey | HEHSUGMKUBTCGE-YTFSRNRJSA-N |
| Nucleoside | thymidine |
| Sugar protection | 3'-O-TBDPS |
| Sugar modification | 2'-deoxy |
| Hydroxyl state | free 5' hydroxyl |
| InChI | InChI=1S/C26H32N2O5Si/c1-18-16-28(25(31)27-24(18)30)23-15-21(22(17-29)32-23)33-34(26(2,3)4,19-11-7-5-8-12-19)20-13-9-6-10-14-20/h5-14,16,21-23,29H,15,17H2,1-4H3,(H,27,30,31)/t21-,22+,23+/m0/s1 |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C3=CC=CC=C3)(C4=CC=CC=C4)C(C)(C)C |
| Canonical SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C3=CC=CC=C3)(C4=CC=CC=C4)C(C)(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Related products
2'-O-TBDMS-rG(iBu)
Protected Nucleosides · CAS: 182007-86-9
OR-PN-00435'-O-DMTr-2'-O-TBDMS-rC(Ac)
Protected Nucleosides · CAS: 121058-85-3
OR-PN-00575'-O-TBDMS-3'-O-TBDMS-5-(hydroxymethyl)-dC
Protected Nucleosides · CAS: 1257247-39-4
OR-PN-00585'-O-TBDMS-3'-O-TBDMS-5-I-dC
Protected Nucleosides · CAS: 478843-96-8
OR-PN-00673'-O-TBDMS-2'-F-dG(iBu)
Protected Nucleosides · CAS: 2382967-92-0
OR-PN-00683'-O-TBDMS-2'-F-dA(Bz)
Protected Nucleosides · CAS: 1244763-25-4
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Request a quote Review request checklist
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.