Modified Nucleosides
4-Thiouridine
Quick view. A beta-D-ribonucleoside in which the carbonyl oxygen at uracil C4 is replaced by sulfur, CAS 13957-31-8. CAS 13957-31-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
4-Thiouridine is classified as modified nucleosides (Formula C9H12N2O5S; molecular weight 260.27).
Reported in Nature Protocols 2020 for TTchem-seq workflows that label and capture newly synthesized RNA using 4-thiouridine.
For 4-Thiouridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 4sU
- 4-Thio-D-uridine
- Uridine, 4-thio-
Useful catalog search terms
- CAS 13957-31-8
- PubChem CID 3032615
- Wikidata Q20890501
Physicochemical data
| IUPAC name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one |
|---|---|
| InChI | InChI=1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | ZLOIGESWDJYCTF-XVFCMESISA-N |
| SMILES | C1=CN(C(=O)NC1=S)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
| Nucleobase modification | Uracil C4 thione |
| Sugar | beta-D-Ribofuranose |
| Hydroxyl state | Free 2', 3' and 5' hydroxyls |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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