Amino-modified Nucleosides
5-Aminomethyl-2',3'-O-isopropylidene-2-thiouridine
Quick view. A 5-aminomethyl-2-thiouridine derivative bearing a cyclic 2',3'-O-isopropylidene group, CAS 1428903-07-4. CAS 1428903-07-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Aminomethyl-2',3'-O-isopropylidene-2-thiouridine is classified as amino-modified nucleosides (Formula C13H19N3O5S; molecular weight 329.37).
5-Aminomethyl-2',3'-O-isopropylidene-2-thiouridine — A protected 5-aminomethyl-2-thiouridine intermediate for research use in modified nucleoside synthesis.
For 5-Aminomethyl-2',3'-O-isopropylidene-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 5-Aminomethyl-2',3'-di-O-isopropylidene 2-thiouridine
- TNU1409
Useful catalog search terms
- 5-(Aminomethyl)-2',3'-O-isopropylidene-2-thiouridine
- 1428903-07-4
Physicochemical data
| SMILES | CC1(O[C@@H]2[C@H](O[C@H]([C@@H]2O1)N3C=C(C(=O)NC3=S)CN)CO)C |
|---|---|
| Nucleoside | 2-Thiouridine |
| Amino modification | 5-Aminomethyl |
| Sugar protection | Cyclic 2',3'-O-isopropylidene |
| Hydroxyl state | Free 5'-OH |
| PubChem CID | 168449032 |
| InChIKey | LLYVIOOQSMCMDM-TURQNECASA-N |
| InChI | InChI=1S/C13H19N3O5S/c1-13(2)20-8-7(5-17)19-11(9(8)21-13)16-4-6(3-14)10(18)15-12(16)22/h4,7-9,11,17H,3,5,14H2,1-2H3,(H,15,18,22)/t7-,8-,9-,11-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-Aminomethyl-2',3'-O-isopropylidene-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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