Halogenated Nucleosides
5-Bromo-2'-O-methyluridine
Quick view. A uridine nucleoside bearing bromine at pyrimidine C5 and a methoxy substituent at sugar 2'-oxygen. CAS 34218-83-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Bromo-2'-O-methyluridine is classified as 5-bromo-2'-o-methyl uridine nucleoside (Formula C10H13BrN2O6; molecular weight 337.12 g/mol).
5-Bromo-2'-O-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-Bromo-2'-O-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 34218-83-2
- BDJBSBZVARUGEX-JXOAFFINSA-N
Physicochemical data
| PubChem CID | 66760234 |
|---|---|
| IUPAC name | 5-bromo-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione |
| InChIKey | BDJBSBZVARUGEX-JXOAFFINSA-N |
| InChI | InChI=1S/C10H13BrN2O6/c1-18-7-6(15)5(3-14)19-9(7)13-2-4(11)8(16)12-10(13)17/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6-,7-,9-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Br)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Bromo-2'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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