2'-O-Me Nucleosides
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-cytidine
Quick view. Protected 2'-O-methylcytidine derivative bearing a furan-2-yl substituent at C5 and a 5'-O-DMTr group. CAS 2095417-02-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-cytidine is classified as 2'-o-me nucleosides (Formula C35H35N3O8; molecular weight 625.68 g/mol).
5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-cytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-cytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2095417-02-8
Physicochemical data
| Nucleoside | cytidine |
|---|---|
| C5 substituent | furan-2-yl |
| Sugar modification | 2'-O-methyl |
| 5' protection | DMTr |
| InChIKey | BVCNNNKIJMNDAV-WTGZKXAYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-(Furan-2-yl)-2'-O-methyl-5'-O-DMTr-cytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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