Protected Nucleosides
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine
Quick view. A protected uridine derivative bearing 5'-O-DMTr and 3'-O-methyl substitution, identified by CAS 127212-40-2. CAS 127212-40-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine is classified as protected nucleosides (Formula C31H32N2O8; molecular weight 560.59).
5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-3'-O-methyluridine
Useful catalog search terms
- 127212-40-2
Physicochemical data
| Protecting groups | 5'-O-DMTr; 3'-O-methyl |
|---|---|
| 2' position | Free hydroxyl |
| PubChem CID | 23257699 |
| InChI | InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)40-19-25-28(39-3)27(35)29(41-25)33-18-17-26(34)32-30(33)36/h4-18,25,27-29,35H,19H2,1-3H3,(H,32,34,36)/t25-,27-,28-,29-/m1/s1 |
| InChIKey | LJKUDZBDDONJRW-YXINZVNLSA-N |
| SMILES | CO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-O-(4,4'-Dimethoxytrityl)-3'-O-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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