Halogenated Nucleosides
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine
Quick view. A 5'-O-acetyl-protected unsaturated 5-fluorouridine derivative for structure-specific halogenated-nucleoside synthesis research. CAS 160203-74-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine is classified as halogenated nucleosides (Formula C11H11FN2O5; molecular weight 270.21).
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine — 5'-O-acetyl-protected unsaturated 5-fluorouridine derivative for structure-specific halogenated-nucleoside synthesis research.
For 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Useful catalog search terms
- CAS 160203-74-7
- PubChem CID 11076487
Physicochemical data
| PubChem CID | 11076487 |
|---|---|
| InChIKey | KMQULMAOYWPJKG-IONNQARKSA-N |
| IUPAC name | [(2S,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methyl acetate |
| SMILES | CC(=O)OC[C@@H]1C=C[C@@H](O1)N2C=C(C(=O)NC2=O)F |
| Nucleobase modification | 5-fluoro |
| Sugar modification | 2',3'-dideoxy-2',3'-didehydro |
| Protecting group | 5'-O-acetyl |
| InChI | InChI=1S/C11H11FN2O5/c1-6(15)18-5-7-2-3-9(19-7)14-4-8(12)10(16)13-11(14)17/h2-4,7,9H,5H2,1H3,(H,13,16,17)/t7-,9+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-5-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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