Intermediates
5-Trifluoromethyluracil-1-yl acetic acid methyl ester
Quick view. Uracil derivative bearing a 5-trifluoromethyl group and an N1-linked acetic acid methyl ester side chain. CAS 2072152-16-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Trifluoromethyluracil-1-yl acetic acid methyl ester is classified as intermediates (Formula C8H7F3N2O4; molecular weight 252.15 g/mol).
5-Trifluoromethyluracil-1-yl acetic acid methyl ester is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Trifluoromethyluracil-1-yl acetic acid methyl ester, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2072152-16-8
Physicochemical data
| Heterocycle scaffold | 5-trifluoromethyluracil |
|---|---|
| N1 substituent | acetic acid methyl ester |
| InChIKey | QRVFPKMTCICLNR-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Trifluoromethyluracil-1-yl acetic acid methyl ester or its named chemical feature. Broader product-family guidance is maintained on the category page.
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