Modified Nucleosides
6-O-Methyl-2'-O-methylinosine
Quick view. 6-O-Methyl-2'-O-methylinosine is listed for research-use inquiry under Modified Nucleosides. Its identity is controlled by the retained exact structure and product-form evidence because no public CAS Registry Number is assigned. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
6-O-Methyl-2'-O-methylinosine is classified as modified nucleosides (Formula C12H16N4O5; molecular weight 296.28).
6-O-Methyl-2'-O-methylinosine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 6-O-Methyl-2'-O-methylinosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Physicochemical data
| CAS status | No public CAS assigned |
|---|---|
| Identity control | Reviewed exact name, structure, and product form |
| InChIKey | RANRQDGFSSNRRK-WOUKDFQISA-N |
| InChI | InChI=1S/C12H16N4O5/c1-19-9-8(18)6(3-17)21-12(9)16-5-15-7-10(16)13-4-14-11(7)20-2/h4-6,8-9,12,17-18H,3H2,1-2H3/t6-,8-,9-,12-/m1/s1 |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3OC)CO)O |
| Canonical SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CN=C3OC)CO)O |
| PubChem CID | 170902893 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 6-O-Methyl-2'-O-methylinosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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