Cap Analogs
A(5')ppp(5')(2'-OMeA)pG tetraammonium
Quick view. A no-CAS trinucleotide cap analog in tetraammonium form for co-transcriptional mRNA capping research. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
A(5')ppp(5')(2'-OMeA)pG tetraammonium is classified as cap analogs.
A(5')ppp(5')(2'-OMeA)pG tetraammonium — Trinucleotide cap analog for co-transcriptional mRNA capping in in-vitro-transcription research.
For A(5')ppp(5')(2'-OMeA)pG tetraammonium, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- CAP A(5')ppp(5')(2'-OMeA)pG Ammonium Salt
- CAP A(5')ppp(5')(2'-OMeA)pG
Physicochemical data
| Counterion form | Tetraammonium |
|---|---|
| Nucleotide shorthand | A(5')ppp(5')(2'-OMeA)pG |
| Nucleotide order | Adenosine - 2'-O-methyladenosine - guanosine |
| Phosphate architecture | 5'-5' triphosphate bridge and one internucleotide phosphate |
| Free-acid molecular formula | C31H41N15O23P4 |
| Formula basis | Free-acid form |
| Free-acid molecular weight | 1115.65 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe A(5')ppp(5')(2'-OMeA)pG tetraammonium or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-CA-0005CAP 6 m7G(LNA)(5')ppp(5')(2'OMeA)pG Triammonium Salt
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OR-CA-0006CAP 7 m7G(HNA)(5')ppp(5')(2'OMeA)pG Ammonium Salt
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OR-CA-0007CAP 9 m7G(2'F)(5')ppp(5')(2'OMeA)pG Ammonium Salt
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Product-family literature
These publications provide peer-reviewed context for the Cap Analogs product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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