2'-Fluoro Phosphoramidites
DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite
Quick view. An N6-benzoyl-protected 2'-fluoro deoxyadenosine D-DPSE phosphoramidite monomer for research-use oligonucleotide synthesis. CAS 1528734-00-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite is classified as protected 2'-fluoro deoxyadenosine d-dpse phosphoramidite (Formula C57H56FN6O7PSi; molecular weight 1015.15).
DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite — This protected D-DPSE phosphoramidite is cataloged as a monomer for research-use nucleic acid synthesis.
For DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite
- DMTr-2'-fluoro-N6-benzoyl-dA D-DPSE phosphoramidite
Useful catalog search terms
- CAS 1528734-00-0
- D-DPSE adenosine phosphoramidite
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| Sugar modification | 2'-fluoro-2'-deoxy |
| Phosphorus protecting group | (D)-2-diphenylmethylsilylethyl (DPSE) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dA(Bz)-3'-(D)-DPSE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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OR-2FP-0007DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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