2'-O-Me Phosphoramidites
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is an N6-benzoyl-protected 2'-O-methyl adenosine building block for research-use oligonucleotide synthesis. CAS 110782-31-5. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite is classified as protected 2'-o-methyl adenosine phosphoramidite (Formula C48H54N7O8P; molecular weight 888.00).
DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite — N6-benzoyl-protected 2'-O-methyl adenosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2'-OMe-A(Bz) Phosphoramidite
- DMT-2'-O-methyl-rA(Bz) Phosphoramidite
- N6-Benzoyl-5'-O-DMTr-2'-O-methyladenosine-3'-CE Phosphoramidite
Useful catalog search terms
- 110782-31-5
- PubChem 13872235
- C48H54N7O8P
- Thermo Fisher 27-2042-10
- Areterna PA011
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| Ribose modification | 2'-O-methyl |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | AZCGOTUYEPXHMJ-PSVHYZMASA-N |
| InChI | InChI=1S/C48H54N7O8P/c1-32(2)55(33(3)4)64(61-28-14-27-49)63-42-40(62-47(43(42)59-7)54-31-52-41-44(50-30-51-45(41)54)53-46(56)34-15-10-8-11-16-34)29-60-48(35-17-12-9-13-18-35,36-19-23-38(57-5)24-20-36)37-21-25-39(58-6)26-22-37/h8-13,15-26,30-33,40,42-43,47H,14,28-29H2,1-7H3,(H,50,51,53,56)/t40-,42-,43-,47-,64?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe DMTr-2'-O-Me-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.