RNA (2'-O-TBDMS) Phosphoramidites
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite
Quick view. DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite is an N1-methylpseudouridine and 2'-O-TBDMS protected building block for research-use RNA oligonucleotide synthesis. CAS 875302-45-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite is classified as modified pseudouridine phosphoramidite (Formula C46H63N4O9PSi; molecular weight 875.10).
DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite — N1-methylpseudouridine and 2'-O-TBDMS protected phosphoramidite building block for research-use RNA oligonucleotide synthesis.
For DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- N1-Methylpseudouridine CEP
- DMT-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite
- 5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
Useful catalog search terms
- 875302-45-7
- PubChem 167312621
- C46H63N4O9PSi
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Nucleoside modification | N1-methylpseudouridine |
|---|---|
| Ribose protection | 2'-O-TBDMS |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | ZDZLHJPETUXZJT-NSASEYFNSA-N |
| InChI | InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-41-39(57-40(38-29-49(8)44(52)48-43(38)51)42(41)59-61(11,12)45(5,6)7)30-55-46(33-17-14-13-15-18-33,34-19-23-36(53-9)24-20-34)35-21-25-37(54-10)26-22-35/h13-15,17-26,29,31-32,39-42H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40+,41-,42+,60?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)C2=CN(C(=O)NC2=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC |
| PubChem CID | 167312621 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
These points describe DMTr-2'-O-TBDMS-N1-Me-pseudoU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.