Halogenated Nucleosides
N2-Isobutyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine
Quick view. Protected guanosine derivative bearing N2-isobutyroyl, 5'-O-DMT, and 3'-deoxy-3'-fluoro features. CAS 2080404-19-7. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N2-Isobutyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is classified as halogenated nucleosides (Formula C35H36FN5O7; molecular weight 657.70 g/mol).
N2-Isobutyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For N2-Isobutyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2080404-19-7
Physicochemical data
| Nucleoside | guanosine |
|---|---|
| Base protection | N2-isobutyroyl |
| 5' protection | DMT |
| Sugar modification | 3'-deoxy-3'-fluoro |
| InChIKey | DHDSAIMYCCHNMS-UNVYQVKTSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N2-Isobutyroyl-5'-O-DMT-3'-deoxy-3'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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