Modified Nucleosides
1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-beta-D-ribo-hex-5-enofuranosyl]uracil
Quick view. 2'-O-methyl uracil nucleoside derivative bearing an E-configured ethenylphosphonic-acid terminus. CAS 2095417-50-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-beta-D-ribo-hex-5-enofuranosyl]uracil is classified as modified nucleosides (Formula C11H15N2O8P; molecular weight 334.22 g/mol).
1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-beta-D-ribo-hex-5-enofuranosyl]uracil can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-beta-D-ribo-hex-5-enofuranosyl]uracil, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- [(E)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methoxyoxolan-2-yl]ethenyl]phosphonic acid
Useful catalog search terms
- 2095417-50-6
Physicochemical data
| Base scaffold | Uracil nucleoside |
|---|---|
| Sugar modification | 2'-O-methyl |
| Terminal group | Ethenylphosphonic acid |
| Alkene geometry | E |
| InChIKey | RLNFGWYHHIDGLE-JKXAUABFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-beta-D-ribo-hex-5-enofuranosyl]uracil or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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