Halogenated Nucleosides
2-Chloro-N6-(4-trifluoromethylbenzyl)adenosine
Quick view. A modified adenosine bearing chlorine at purine C2 and a 4-trifluoromethylbenzylamino substituent at C6, identified by CAS 722515-03-9. CAS 722515-03-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2-Chloro-N6-(4-trifluoromethylbenzyl)adenosine is classified as halogenated nucleosides (Formula C18H17ClF3N5O4; molecular weight 459.80).
2-Chloro-N6-(4-trifluoromethylbenzyl)adenosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2-Chloro-N6-(4-trifluoromethylbenzyl)adenosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- (2R,3R,4S,5R)-2-[2-chloro-6-[[4-(trifluoromethyl)phenyl]methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Useful catalog search terms
- CAS 722515-03-9
- PubChem CID 168448733
Physicochemical data
| Halogen position | Purine C2 chlorine |
|---|---|
| N6 substituent | 4-trifluoromethylbenzyl |
| InChIKey | BAZYLCHTDOGGPT-XNIJJKJLSA-N |
| PubChem CID | 168448733 |
| InChI | InChI=1S/C18H17ClF3N5O4/c19-17-25-14(23-5-8-1-3-9(4-2-8)18(20,21)22)11-15(26-17)27(7-24-11)16-13(30)12(29)10(6-28)31-16/h1-4,7,10,12-13,16,28-30H,5-6H2,(H,23,25,26)/t10-,12-,13-,16-/m1/s1 |
| SMILES | C1=CC(=CC=C1CNC2=C3C(=NC(=N2)Cl)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(F)(F)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2-Chloro-N6-(4-trifluoromethylbenzyl)adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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