Reverse Phosphoramidites
2'-F-dG(iBu)-CE-Reverse Phosphoramidite
Quick view. 2'-F-dG(iBu)-CE-Reverse Phosphoramidite is a protected 2'-fluoro guanosine building block with 3'-O-DMTr protection, an N2-isobutyryl group and a 5'-cyanoethyl N,N-diisopropyl phosphoramidite. The reviewed identity corresponds to PubChem CID 169074193. CAS 2757763-07-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-F-dG(iBu)-CE-Reverse Phosphoramidite is classified as protected 2'-fluoro purine nucleoside reverse phosphoramidite (Formula C44H53FN7O8P; molecular weight 857.91).
2'-F-dG(iBu)-CE-Reverse Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-F-dG(iBu)-CE-Reverse Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-2'-F-dG(iBu)-5'-CE-Phosphoramidite
- 3'-DMT-2'-F-dG(iBu)-CE Reverse
Useful catalog search terms
- CAS 2757763-07-6
- Reverse Phosphoramidites
Physicochemical data
| PubChem CID | 169074193 |
|---|---|
| InChIKey | LWQNQPOOAQJXAZ-AOCJBPQJSA-N |
| Structural features | 3'-O-DMTr; 2'-fluoro; N2-isobutyryl guanine; 5'-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChI | InChI=1S/C44H53FN7O8P/c1-27(2)40(53)49-43-48-39-37(41(54)50-43)47-26-51(39)42-36(45)38(35(59-42)25-58-61(57-24-12-23-46)52(28(3)4)29(5)6)60-44(30-13-10-9-11-14-30,31-15-19-33(55-7)20-16-31)32-17-21-34(56-8)22-18-32/h9-11,13-22,26-29,35-36,38,42H,12,24-25H2,1-8H3,(H2,48,49,50,53,54)/t35-,36-,38-,42-,61?/m1/s1 |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(N(C(C)C)C(C)C)OCCC#N)OC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dG(iBu)-CE-Reverse Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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