Modified Nucleosides
2'-O,4'-C-Methyleneuridine
Quick view. Bicyclic uridine derivative containing a methylene bridge between the 2'-oxygen and 4'-carbon, with free 3' and 5' hydroxyl groups. CAS 200435-92-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O,4'-C-Methyleneuridine is classified as modified nucleosides (Formula C10H12N2O6; molecular weight 256.21 g/mol).
2'-O,4'-C-Methyleneuridine is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For 2'-O,4'-C-Methyleneuridine, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-U
- LNA-Uridine
- LNA-U diol
- 1-(2'-O,4'-C-Methylene-beta-D-ribofuranosyl)uridine
- 1-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]uracil
Useful catalog search terms
- 200435-92-3
Physicochemical data
| Bridge | 2'-O,4'-C-methylene |
|---|---|
| Nucleobase | Uracil |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O,4'-C-Methyleneuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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