2'-O-Me Nucleosides
2'-O-Methyl-5-hydroxymethyluridine
Quick view. A uridine nucleoside bearing a 2'-O-methyl sugar modification and a 5-hydroxymethyl base modification. CAS 910050-95-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyl-5-hydroxymethyluridine is classified as 2'-o-me nucleosides (Formula C11H16N2O7; molecular weight 288.25 g/mol).
2'-O-Methyl-5-hydroxymethyluridine — 2'-O-methyl modified uridine building block for downstream nucleoside chemistry.
For 2'-O-Methyl-5-hydroxymethyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5-(Hydroxymethyl)-2'-O-methyluridine
Useful catalog search terms
- 910050-95-2
- 91827907
Physicochemical data
| PubChem CID | 91827907 |
|---|---|
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)CO)CO)O |
| Nucleoside | Uridine |
| Sugar modification | 2'-O-Methyl |
| Base modification | 5-Hydroxymethyl |
| InChIKey | ZJQLVUOUHLNLDA-FDDDBJFASA-N |
| InChI | InChI=1S/C11H16N2O7/c1-19-8-7(16)6(4-15)20-10(8)13-2-5(3-14)9(17)12-11(13)18/h2,6-8,10,14-16H,3-4H2,1H3,(H,12,17,18)/t6-,7-,8-,10-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5-hydroxymethyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.