2'-O-Me Nucleosides
2'-O-Methyl-5-methyl-4-thiouridine
Quick view. 2'-O-Methyluridine derivative bearing a 5-methyl group and a 4-thioxo base modification. CAS 2095417-26-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyl-5-methyl-4-thiouridine is classified as 2'-o-me nucleosides (Formula C11H16N2O5S; molecular weight 288.32 g/mol).
2'-O-Methyl-5-methyl-4-thiouridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-5-methyl-4-thiouridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2095417-26-6
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Base modification | 5-methyl-4-thio |
| 2' modification | O-methyl |
| InChIKey | UIBLINQYGJCXTO-FDDDBJFASA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5-methyl-4-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.