Base-protected Nucleosides
2'-O-MOE-rC(Bz)
Quick view. N4-Benzoyl cytidine bearing a 2'-O-(2-methoxyethyl) group and free 3'- and 5'-hydroxyl groups. CAS 2305416-18-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-MOE-rC(Bz) is classified as base-protected nucleosides (Formula C19H23N3O7; molecular weight 405.41).
2'-O-MOE-rC(Bz) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 2'-O-MOE-rC(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-2'-O-(2-methoxyethyl)cytidine
- N4-Bz-2'-O-MOE-rC
- 2'-O-MOE-N4-Bz-cytidine
Useful catalog search terms
- CAS 2305416-18-4
Physicochemical data
| Nucleoside | Cytidine |
|---|---|
| Base protection | N4-benzoyl |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.