2'-O-Me Nucleosides
2'-O-Methylpseudouridine
Quick view. Pseudouridine derivative bearing a methyl ether at the ribose 2'-oxygen. CAS 2140-68-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methylpseudouridine is classified as 2'-o-me nucleosides (Formula C10H14N2O6; molecular weight 258.23 g/mol).
2'-O-Methylpseudouridine is relevant to modified RNA, mRNA optimization, epitranscriptomic standards or immune-recognition studies depending on the format supplied.
For 2'-O-Methylpseudouridine, modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
Names and search terms
Confirmed or normalized name variants
- 2'-O-Me-pseudouridine
Useful catalog search terms
- 2140-68-3
Physicochemical data
| Nucleoside | Pseudouridine |
|---|---|
| 2' substitution | O-methyl |
| Protection state | Unprotected |
| InChIKey | WGNUTGFETAXDTJ-OOJXKGFFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Base modifications can tune RNA stability, translation behavior, duplex properties or analytical discrimination versus native bases.
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Modification benefits are context-dependent; transcript length, substitution level, enzyme system and analytical purity can change the observed outcome.
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methylpseudouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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