Modified Nucleosides
2-Thiouridine
Quick view. Uridine derivative in which sulfur replaces the C2 carbonyl oxygen of the uracil base, with free 2', 3', and 5' hydroxyl groups. CAS 20235-78-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2-Thiouridine is classified as modified nucleosides (Formula C9H12N2O5S; molecular weight 260.27 g/mol).
2-Thiouridine is associated with uridine-containing substrates for U-position incorporation in RNA or modified RNA studies.
For 2-Thiouridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 2-Thio-D-uridine
- 1-beta-D-Ribofuranosyl-2-thiouracil
- Uridine, 2-thio-
- s2U
Useful catalog search terms
- 20235-78-3
Physicochemical data
| Nucleobase modification | Uracil C2 thione |
|---|---|
| Sugar | beta-D-ribofuranose |
| Hydroxyl state | 2', 3', and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | GJTBSTBJLVYKAU-XVFCMESISA-N |
| SMILES | C1=CN(C(=S)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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