TIPDS-protected Nucleosides
3',5'-O-TIPDS-rG(Pac)
Quick view. 3',5'-O-TIPDS-rG(Pac) is N2-phenoxyacetylguanosine protected by a 3',5'-O-TIPDS bridge, leaving the 2'-hydroxyl unprotected. CAS 131474-72-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3',5'-O-TIPDS-rG(Pac) is classified as tipds-protected nucleosides (Formula C30H45N5O8Si2; molecular weight 659.90).
3',5'-O-TIPDS-rG(Pac) — Protected guanosine intermediate for research route development involving the free 2'-hydroxyl.
For 3',5'-O-TIPDS-rG(Pac), confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- N2-phenoxyacetyl-3',5'-O-TIPDS-guanosine
Useful catalog search terms
- CAS 131474-72-1
Physicochemical data
| Protecting-group pattern | N2-phenoxyacetyl; 3',5'-O-TIPDS bridge |
|---|---|
| Unprotected position | 2'-hydroxyl |
| Encoded stereochemistry | (6aR,8R,9R,9aS) |
| Systematic name | N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-6-oxo-1H-purin-2-yl]-2-phenoxyacetamide |
| InChIKey | RRWDFNRJFKNJIJ-QTWDEJAXSA-N |
| InChI | InChI=1S/C30H45N5O8Si2/c1-17(2)44(18(3)4)40-14-22-26(42-45(43-44,19(5)6)20(7)8)25(37)29(41-22)35-16-31-24-27(35)33-30(34-28(24)38)32-23(36)15-39-21-12-10-9-11-13-21/h9-13,16-20,22,25-26,29,37H,14-15H2,1-8H3,(H2,32,33,34,36,38)/t22-,25-,26-,29-/m1/s1 |
| SMILES | CC(C)[Si]1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)NC(=O)COC5=CC=CC=C5)O)O[Si](O1)(C(C)C)C(C)C)C(C)C |
| Canonical SMILES | CC(C)[Si]1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)NC(=O)COC5=CC=CC=C5)O)O[Si](O1)(C(C)C)C(C)C)C(C)C |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the TIPDS-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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