Halogenated Nucleosides
3'-Deoxy-3'-fluoroinosine
Quick view. 3'-Deoxy-3'-fluoroinosine is an inosine nucleoside bearing fluorine at sugar C3', with CAS 117517-20-1. CAS 117517-20-1. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-Deoxy-3'-fluoroinosine is classified as 3'-fluoro inosine nucleoside (Formula C10H11FN4O4; molecular weight 270.22).
3'-Deoxy-3'-fluoroinosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 3'-Deoxy-3'-fluoroinosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-Fluoro-3'-deoxyinosine
- TNU0201
- CHEMBL4869277
- RefChem:90359
- PubChem CID 135503550
- Wikidata Q82895967
Useful catalog search terms
- CAS 117517-20-1
Physicochemical data
| IUPAC name | 9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one |
|---|---|
| InChI | InChI=1S/C10H11FN4O4/c11-5-4(1-16)19-10(7(5)17)15-3-14-6-8(15)12-2-13-9(6)18/h2-5,7,10,16-17H,1H2,(H,12,13,18)/t4-,5-,7-,10-/m1/s1 |
| InChIKey | POYFYFKHABGRAR-QYYRPYCUSA-N |
| SMILES | C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)F)O |
| Structural feature | Fluorine replaces the 3'-hydroxyl group |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-Deoxy-3'-fluoroinosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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