Modified Nucleosides
3'-O-(2-Methoxyethyl)guanosine
Quick view. Guanosine derivative bearing a 3'-O-(2-methoxyethyl) substituent, with free 2'- and 5'-hydroxyl groups. CAS 256224-03-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
3'-O-(2-Methoxyethyl)guanosine is classified as modified nucleosides (Formula C13H19N5O6; molecular weight 341.32 g/mol).
3'-O-(2-Methoxyethyl)guanosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 3'-O-(2-Methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 3'-O-MOE-guanosine
Useful catalog search terms
- 256224-03-0
Physicochemical data
| Systematic name | 2-amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-(2-methoxyethoxy)oxolan-2-yl]-1H-purin-6-one |
|---|---|
| Chemical form | Neutral 3'-O-MOE-modified guanosine |
| Structural scope | 3'-O-(2-methoxyethyl) substitution with free 2'- and 5'-hydroxyl groups |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | BPFOZTYDUWLNNN-WOUKDFQISA-N |
| SMILES | COCCO[C@@H]1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2N=C(NC3=O)N)CO |
| InChI | InChI=1S/C13H19N5O6/c1-22-2-3-23-9-6(4-19)24-12(8(9)20)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1 |
| PubChem CID | 157419388 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 3'-O-(2-Methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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