2'-O-Me Nucleosides
4',5'-Didehydro-2'-O-methyl-5-methyluridine
Quick view. 5-Methyluridine derivative bearing a 2'-O-methyl group and a terminal-methylene 4',5'-unsaturated sugar moiety. CAS 2095417-11-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
4',5'-Didehydro-2'-O-methyl-5-methyluridine is classified as 2'-o-me nucleosides (Formula C11H14N2O5; molecular weight 254.24 g/mol).
4',5'-Didehydro-2'-O-methyl-5-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 4',5'-Didehydro-2'-O-methyl-5-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- 2095417-11-9
Physicochemical data
| Nucleoside | 5-methyluridine |
|---|---|
| Sugar modification | 4',5'-didehydro terminal methylene |
| 2' modification | O-methyl |
| Calculated InChIKey | YVDWDRXYCAHSJC-NQMVMOMDSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 4',5'-Didehydro-2'-O-methyl-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.