Amino-modified Nucleosides
5'-Azido-2',5'-dideoxyadenosine
Quick view. An adenosine derivative with the 2'-hydroxyl absent and an azido group at the 5' position, CAS 42204-43-3. CAS 42204-43-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Azido-2',5'-dideoxyadenosine is classified as 5'-azido dideoxy purine nucleoside (Formula C10H12N8O2; molecular weight 276.26 g/mol).
5'-Azido-2',5'-dideoxyadenosine — An azido nucleoside intermediate used in the primary literature to prepare 5'-amino-2',5'-dideoxyadenosine.
For 5'-Azido-2',5'-dideoxyadenosine, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 9-(5-Azido-2,5-dideoxypentofuranosyl)-9H-purin-6-amine
Useful catalog search terms
- 42204-43-3
- C10H12N8O2
- 5'-azido adenosine
- azido nucleoside
Physicochemical data
| Nucleobase | Adenine |
|---|---|
| Sugar modification | 2'-deoxy and 5'-azido |
| InChI | InChI=1S/C10H12N8O2/c11-9-8-10(14-3-13-9)18(4-15-8)7-1-5(19)6(20-7)2-16-17-12/h3-7,19H,1-2H2,(H2,11,13,14) |
| InChIKey | GCTRYQSKALFXJD-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCC1OC(n2cnc3c(N)ncnc32)CC1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-Azido-2',5'-dideoxyadenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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Technology platforms
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