Modified Nucleosides
5-Carboxymethyl-2-thiouridine
Quick view. A uridine derivative bearing a carboxymethyl substituent at C5 and thioxo substitution at C2, commonly abbreviated cm5s2U. CAS 58479-77-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Carboxymethyl-2-thiouridine is classified as 5-substituted 2-thiouridine nucleoside (Formula C11H14N2O7S; molecular weight 318.30 g/mol).
5-Carboxymethyl-2-thiouridine — Recognized in RNA-modification literature as cm5s2U and discussed in pathways that distinguish carboxymethyl from methoxycarbonylmethyl uridine derivatives.
For 5-Carboxymethyl-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2-Thio-5-carboxymethyluridine
- cm5s2U
Useful catalog search terms
- 58479-77-9
- MSGFOEBMIJOVCL-VPCXQMTMSA-N
Physicochemical data
| InChIKey | MSGFOEBMIJOVCL-VPCXQMTMSA-N |
|---|---|
| InChI | InChI=1S/C11H14N2O7S/c14-3-5-7(17)8(18)10(20-5)13-2-4(1-6(15)16)9(19)12-11(13)21/h2,5,7-8,10,14,17-18H,1,3H2,(H,15,16)(H,12,19,21)/t5-,7-,8-,10-/m1/s1 |
| SMILES | O=C(O)Cc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=S)nc1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-Carboxymethyl-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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