ddNTPs
5-CF3-ddUTP Sodium Salt
Quick view. A 5-trifluoromethyl-substituted 2',3'-dideoxyuridine triphosphate in sodium-salt form; formula and weight describe the parent free acid. CAS 730926-66-6. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-CF3-ddUTP Sodium Salt is classified as ddntps.
5-CF3-ddUTP Sodium Salt can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 5-CF3-ddUTP Sodium Salt, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- 5-(Trifluoromethyl)-ddUTP
- 5-CF3-2',3'-dideoxyuridine triphosphate
Useful catalog search terms
- CAS 730926-66-6
Physicochemical data
| PubChem CID | 54326074 |
|---|---|
| Salt form | Sodium salt; sodium stoichiometry unspecified |
| Sugar framework | 2',3'-dideoxyribose; (2S,5R) |
| Base modification | 5-trifluoromethyl uracil |
| InChIKey | SVAMOTVIUFPPJA-CAHLUQPWSA-N |
| InChI | InChI=1S/C10H14F3N2O13P3/c11-10(12,13)6-3-15(9(17)14-8(6)16)7-2-1-5(26-7)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h3,5,7H,1-2,4H2,(H,21,22)(H,23,24)(H,14,16,17)(H2,18,19,20)/t5-,7+/m0/s1 |
| SMILES | C1C[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=C(C(=O)NC2=O)C(F)(F)F |
| Canonical SMILES | C1C[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=C(C(=O)NC2=O)C(F)(F)F |
| Structure representation | Free-acid nucleotide parent; sodium stoichiometry is not represented |
| Free-acid molecular formula | C10H14F3N2O13P3 |
| Formula basis | Free-acid form |
| Free-acid molecular weight | 520.14 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5-CF3-ddUTP Sodium Salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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