Halogenated Nucleosides
5-Chloro-2',3'-dideoxy-3'-fluorouridine
Quick view. 5-Chloro-2',3'-dideoxy-3'-fluorouridine is a halogenated dideoxynucleoside with CAS 119644-22-3. CAS 119644-22-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Chloro-2',3'-dideoxy-3'-fluorouridine is classified as halogenated nucleosides (Formula C9H10ClFN2O4; molecular weight 264.64).
5-Chloro-2',3'-dideoxy-3'-fluorouridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 5-Chloro-2',3'-dideoxy-3'-fluorouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Raluridine
- PubChem CID 451480
- Wikidata Q27272384
Useful catalog search terms
- CAS 119644-22-3
Physicochemical data
| InChIKey | WKVDSZYIGHLONN-RRKCRQDMSA-N |
|---|---|
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)F |
| Systematic name | 5-chloro-1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Structural feature | 5-chloro base with a 2',3'-dideoxy-3'-fluoro sugar |
| InChI | InChI=1S/C9H10ClFN2O4/c10-4-2-13(9(16)12-8(4)15)7-1-5(11)6(3-14)17-7/h2,5-7,14H,1,3H2,(H,12,15,16)/t5-,6+,7+/m0/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Chloro-2',3'-dideoxy-3'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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