2'-O-Me Nucleosides
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine
Quick view. A 5-methyluridine nucleoside bearing 5'-deoxy-5'-iodo and 2'-O-methyl substitutions, CAS 187733-72-8. CAS 187733-72-8. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine is classified as 2'-o-me nucleosides (Formula C11H15IN2O5; molecular weight 382.15).
5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-deoxy-5'-iodo-5-methyl-2'-O-methyluridine
- Uridine, 5'-deoxy-5'-iodo-5-methyl-2'-O-methyl-
Useful catalog search terms
- CAS 187733-72-8
- C11H15IN2O5
- HTLVQJXEEODLKI-FDDDBJFASA-N
Physicochemical data
| Sugar substitution | 2'-O-methyl |
|---|---|
| 5'-substitution | 5'-Deoxy-5'-iodo |
| Nucleobase substitution | 5-Methyluracil |
| Free hydroxyl | 3'-OH |
| Stereochemistry | Assigned ribofuranosyl configuration |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-Deoxy-5'-iodo-2'-O-methyl-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.