Modified Nucleosides
5-Formyl-2'-O-methylcytidine
Quick view. A cytidine derivative bearing a nucleobase 5-formyl group and a sugar 2'-O-methyl substitution, CAS 176858-79-0. CAS 176858-79-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Formyl-2'-O-methylcytidine is classified as modified nucleosides (Formula C11H15N3O6; molecular weight 285.25).
5-Formyl-2'-O-methylcytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-Formyl-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- f5Cm
- 5-Formyl-2'-O-methylcytidine, RNA-modified nucleoside f5Cm
Useful catalog search terms
- CAS 176858-79-0
- C11H15N3O6
Physicochemical data
| Nucleobase substitution | Cytosine 5-formyl |
|---|---|
| Sugar substitution | 2'-O-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Formyl-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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