Halogenated Nucleosides
5-Iodo-3'-deoxy-3'-fluorouridine
Quick view. Halogenated uridine derivative bearing iodine at the nucleobase 5-position and a 3'-fluoro substituent in place of the 3'-hydroxy group. CAS 2072145-21-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Iodo-3'-deoxy-3'-fluorouridine is classified as halogenated nucleosides (Formula C9H10FIN2O5; molecular weight 372.09 g/mol).
5-Iodo-3'-deoxy-3'-fluorouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Iodo-3'-deoxy-3'-fluorouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2072145-21-0
Physicochemical data
| Nucleobase substitution | 5-iodo |
|---|---|
| Sugar substitution | 3'-fluoro-3'-deoxy |
| PubChem CID | 168448276 |
| InChIKey | VSSVVOWJEMFFSE-UAKXSSHOSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Iodo-3'-deoxy-3'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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