Modified Nucleosides
5-Methoxycarbonylmethyl-2-thiouridine
Quick view. 2-Thiouridine derivative bearing a methoxycarbonylmethyl substituent at C5, with an unprotected beta-D-ribofuranose unit. CAS 20299-15-4. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5-Methoxycarbonylmethyl-2-thiouridine is classified as modified nucleosides (Formula C12H16N2O7S; molecular weight 332.33 g/mol).
5-Methoxycarbonylmethyl-2-thiouridine is associated with uridine-containing substrates for U-position incorporation in RNA or modified RNA studies.
For 5-Methoxycarbonylmethyl-2-thiouridine, confirm the current specification, storage conditions and downstream-method compatibility before routine use.
Names and search terms
Confirmed or normalized name variants
- 5-Pyrimidineacetic acid, 1,2,3,4-tetrahydro-4-oxo-1-beta-D-ribofuranosyl-2-thioxo-, methyl ester
Useful catalog search terms
- 5-(Methoxycarbonylmethyl)-2-thiouridine
- 20299-15-4
Physicochemical data
| Nucleobase modification | Uracil C2 thione and C5 methoxycarbonylmethyl substituent |
|---|---|
| Sugar | beta-D-ribofuranose |
| Hydroxyl state | 2', 3', and 5' hydroxyl groups unprotected |
| InChIKey | HLZXTFWTDIBXDF-PNHWDRBUSA-N |
| InChI | InChI=1S/C12H16N2O7S/c1-20-7(16)2-5-3-14(12(22)13-10(5)19)11-9(18)8(17)6(4-15)21-11/h3,6,8-9,11,15,17-18H,2,4H2,1H3,(H,13,19,22)/t6-,8-,9-,11-/m1/s1 |
| SMILES | COC(=O)CC1=CN(C(=S)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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