Other Phosphoramidites
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite)
Quick view. A protected 2'-O-MOE-5-methylcytidine building block containing two linked phosphoramidite phosphorus centers. CAS N/A. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite) is classified as protected modified-nucleoside bis(phosphoramidite) (Formula C58H78N6O12P2; molecular weight 1113.24).
5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-MOE-5-Me-rC(Bz) bis(phosphoramidite)
Useful catalog search terms
- C58H78N6O12P2
Physicochemical data
| Nucleoside modification | 2'-O-MOE-5-methylcytidine |
|---|---|
| Protecting groups | 5'-O-DMTr; N4-benzoyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.