2'-Fluoro Phosphoramidites
DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite
Quick view. A protected 2'-fluoro guanosine D-DPSE phosphoramidite building block for research-use oligonucleotide synthesis. CAS 2227140-01-2. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite is classified as protected 2'-fluoro guanosine d-dpse phosphoramidite (Formula C54H58FN6O8PSi; molecular weight 997.15).
DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite — This protected D-DPSE phosphoramidite is cataloged as a building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite
Useful catalog search terms
- CAS 2227140-01-2
- CID 178421317
- C54H58FN6O8PSi
Physicochemical data
| PubChem CID | 178421317 |
|---|---|
| InChIKey | GSSYTHNLCHZVRD-NSBBQIGSSA-N |
| Base protection | N2-isobutyryl (iBu) |
| 5' protection | 4,4'-Dimethoxytrityl (DMTr) |
| Sugar modification | 2'-fluoro |
| 3'-function | (D)-DPSE phosphoramidite |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dG(iBu)-3'-(D)-DPSE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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OR-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not an OROGO lot specification or product-performance claim.
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Technology platforms
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