LNA Phosphoramidites
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylenecytidine 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite)
Quick view. Protected LNA cytidine phosphoramidite bearing N4-benzoyl and 5'-O-dimethoxytrityl groups, a 2'-O,4'-C methylene bridge, and a 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite); phosphorus configuration is unspecified. CAS 206055-78-9. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylenecytidine 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite) is classified as lna phosphoramidites (Formula C47H52N5O9P; molecular weight 861.92 g/mol).
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylenecytidine 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite) is useful for high-affinity probes, SNP/mismatch-discrimination studies, antisense designs and short sequence probes.
For N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylenecytidine 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-DMT-LNA-N4-Bz-C phosphoramidite
- N4-Bz-5'-O-DMTr-LNA-C 3'-phosphoramidite
Useful catalog search terms
- N4-Benzoyl-5'-O-DMTr-LNA-C phosphoramidite
- 206055-78-9
Physicochemical data
| Base protection | N4-benzoyl cytosine |
|---|---|
| 5' protection | O-(4,4'-dimethoxytrityl) |
| Sugar modification | 2'-O,4'-C methylene bridge |
| 3' group | 2-cyanoethyl N,N-diisopropyl phosphoramidite |
| Stereochemistry | Carbon configuration defined; phosphorus configuration unspecified |
| InChIKey | SSGINSHBUWKRHC-XCHZTBEFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylenecytidine 3'-O-(2-cyanoethyl N,N-diisopropyl phosphoramidite) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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OR-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
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OR-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
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Feature and workflow background
These publications discuss a broader chemistry feature or workflow identified from the catalog name or product family. They are background reading only, not evidence for the exact OROGO product, supplied form, lot specification, availability or performance.
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