Halogenated Nucleosides
2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine
Quick view. 5-Difluoromethyluridine derivative protected at the 2'-, 3'-, and 5'-hydroxyl groups as benzoates. CAS 2305416-06-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine is classified as halogenated nucleosides (Formula C31H24F2N2O9; molecular weight 606.53 g/mol).
2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Useful catalog search terms
- 2305416-06-0
Physicochemical data
| PubChem CID | 168436201 |
|---|---|
| Nucleoside | 5-Difluoromethyluridine |
| Protecting groups | 2'-O-benzoyl; 3'-O-benzoyl; 5'-O-benzoyl |
| IUPAC name | [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-[5-(difluoromethyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]methyl benzoate |
| InChIKey | HCMYNQAVISEHFG-ANNHOSHMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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