Modified Nucleosides
2',3'-Dideoxyguanosine
Quick view. A guanosine analog with both the 2'- and 3'-hydroxyl groups absent, identified by CAS 85326-06-3. CAS 85326-06-3. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2',3'-Dideoxyguanosine is classified as modified nucleosides (Formula C10H13N5O3; molecular weight 251.24).
2',3'-Dideoxyguanosine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 2',3'-Dideoxyguanosine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Dideoxyguanosine
- ddGuo
Useful catalog search terms
- CAS 85326-06-3
- PubChem CID 135463029
Physicochemical data
| PubChem CID | 135463029 |
|---|---|
| InChIKey | OCLZPNCLRLDXJC-NTSWFWBYSA-N |
| Nucleoside | guanosine |
| Sugar modification | 2',3'-dideoxy |
| Free hydroxyl | 5'-OH |
| InChI | InChI=1S/C10H13N5O3/c11-10-13-8-7(9(17)14-10)12-4-15(8)6-2-1-5(3-16)18-6/h4-6,16H,1-3H2,(H3,11,13,14,17)/t5-,6+/m0/s1 |
| SMILES | N=c1nc(O)c2ncn([C@H]3CC[C@@H](CO)O3)c2[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',3'-Dideoxyguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
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