2'-O-Me Nucleosides
2'-O-Methyl-N2,N2-dimethylguanosine
Quick view. 2'-O-Methyl-N2,N2-dimethylguanosine is a guanosine nucleoside bearing N2,N2-dimethyl and 2'-O-methyl substitutions, with CAS 113886-73-0. CAS 113886-73-0. Catalog target purity: By inquiry. Availability: Inquiry only — contact OROGO to confirm current availability.
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Product profile
2'-O-Methyl-N2,N2-dimethylguanosine is classified as 2'-o-methyl guanosine nucleoside (Formula C13H19N5O5; molecular weight 325.32).
2'-O-Methyl-N2,N2-dimethylguanosine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Methyl-N2,N2-dimethylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2,N2,2'-O-trimethylguanosine
- N,N-Dimethyl-2'-O-methylguanosine
- Guanosine, N,N-dimethyl-2'-O-methyl-
- m22Gm
- MCE HY-152706
Useful catalog search terms
- CAS 113886-73-0
Physicochemical data
| SMILES | CN(C)C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
|---|---|
| Structural feature | N2,N2-dimethyl base and 2'-O-methyl ribose |
| PubChem CID | 135433550 |
| InChIKey | YUCFXTKBZFABID-WOUKDFQISA-N |
| InChI | InChI=1S/C13H19N5O5/c1-17(2)13-15-10-7(11(21)16-13)14-5-18(10)12-9(22-3)8(20)6(4-19)23-12/h5-6,8-9,12,19-20H,4H2,1-3H3,(H,15,16,21)/t6-,8-,9-,12-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-N2,N2-dimethylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
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Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.